Autonomous, uncontrolled cell growth and proliferation are the fundamental characteristics of cancer. The driving forces behind these and other neoplastic systems remain partially understood.
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- Cancer Biomarker Panels - Cancer biomarkers are biological molecules that are indicative of a particular cancer and include proteins, RNAs, antibodies and peptides. Cancer biomarkers are detected in blood or other bodily fluids to monitor cancer progression and predict response to therapy. Find products and resources for your tumor biomarker research.
- Cancer Metabolism - Cancer cells have distinct metabolic changes compared with normal cells. Changes often include increased aerobic glycolysis and a switch from oxidative phosphorylation to lactate production, and an increase in the production of biosynthetic intermediates for biomass production.
- Cell Cycle - Disruption of the normal cell cycle underpins the characteristic uncontrolled cell division in cancer. Deregulation of the cell cycle is a consequence of aberrant activity of cell cycle-associated kinases or phosphatases.
- Cell Death - Cell death plays a very important role in maintaining homeostasis. Cell death can result from infection, cellular or systemic stress, or other cellular signals. Cell death is classified based on the morphological and biochemical characteristics. Cellular death can occur via necrosis, apoptosis, autophagy, necroptosis, pyroptosis, and anoikis.
- Drug Resistance - Cancer resistance to chemotherapy is a major barrier to successful treatment. Resistance is often caused by proteins such as multidrug resistance-associated proteins (MRPs) and P glycoproteins that pump chemotherapy agents from cells, but also occurs due to secondary mutations in drug targets or effectors.
- Growth Factors - Growth factors are key players in tumor progression, and are involved in clonal expansion, tissue invasion and angiogenesis. Important growth factors include vascular endothelial growth factors (VEGF) epidermal growth factors (EGF) and insulin-like growth factors (IGF). Find protocols, pathways and products for your cancer growth factor research.
- Invasion/Microenvironment - The tumor microenvironment refers to the interactions between heterogeneous cell types and the extracellular matrix (ECM) within a cancerous lesion, and mediates the key processes of angiogenesis, ECM remodeling and immunosurveillance inhibition.
- Oncoproteins/Suppressors - Oncoproteins contribute to tumorigenesis, whereas tumor suppressors inhibit cancer progression. We have tools to help you study oncoproteins and suppressors such as growth factors and receptors, transcription factors, viral oncoproteins and p53. Use this page to find products, pathways and protocols for your research.
- Signal Transduction - Cancer is strongly associated with signal transduction changes. Our resources for cancer signal transduction include pathway cards covering cellular apoptosis, Akt, EGF, p53, VEGF and more.
- TumorBiomarkers - Enzymes, Globulins, Hormones, Oncoproteins, Receptor
- Tumor Immunolog - Tumor immunology refers to the interaction of immune cells with cancer cells. T cells and natural killer cells are involved in tumor immunosurveillance. However, the immunosuppressive tumor microenvironment also allows tumor cells to escape detection. Discover protocols and pathways for your cancer immunology and immunotherapy research.
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Mouse monoclonal MRP2 antibody [M2 III-6]
Rabbit polyclonal CD44 antibody
Rabbit monoclonal [EP373Y] to CD34
Rabbit polyclonal to Caspase-3
Rabbit monoclonal [EPR5701] to p63
Rabbit polyclonal to Caveolin-1
Rabbit monoclonal [EPR3554] to MRP8