NextSeq 550Dx System

The NextSeq 550Dx instrument is FDA regulated and CE-in vitro diagnostic (IVD) marked, enabling clinical laboratories to develop and perform a wide range of applications, from NGS IVD assays using targeted panels, to clinical research applications that include methods from targeted panels to whole genomes.

The instrument and sequencing reagents are all regulated by the FDA, developed under design control principles, manufactured under Current Good Manufacturing Practices (cGMPs), and verified for consistent assay performance.

Paired with the TruSeq Custom Amplicon Kit Dx library preparation kit and the NextSeq 550Dx Reagent Kit, the NextSeq 550Dx is part of an IVD development toolkit that enables clinical labs to design clinical assays with regulated components.

Work within a regulated sequencing workflow for developing diagnotic tests and leveraging future NGS IVD tests in the pipeline, while retaining the flexibility to work in a research environment and use the full range of Illumina sequencing methods for a wide range of applications.

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Catalog number
NextSeq 550Dx Instrument
Properties Value
Large Whole-Genome Sequencing (human, plant, animal) +
Small Whole-Genome Sequencing (microbe, virus) +
Exome Sequencing +
Targeted Gene Sequencing +
Transcriptome Sequencing +
Gene Expression Profiling with mRNA-Seq +
Targeted Gene Expression Profiling -
Long-Range Amplicon Sequencing* -
miRNA & Small RNA Analysis +
DNA-Protein Interaction Analysis +
Methylation Sequencing -
16S Metagenomic Sequencing +
Run Time (hours) 12-30
Maximum Output 120 Gb
Maximum Reads Per Run (millions) 400
Maximum Read Length (bp) 2 × 150 bp